Therapeutic Antibodies: Bench to Market

Webinar Series of the Chinese Antibody Society

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The biology of the blood-brain barrier and brain drug delivery

04/29/2023

Wandong Zhang, Ph.D.

The blood-brain barrier (BBB) is a biological property of the brain microvessels and capillaries and plays a critical role in maintaining the physiological functions and homeostasis of central nervous system (CNS). BBB facilitates the passage of nutrients (such as amino acids, glucose, and nucleotides) into the CNS, exports metabolic wastes, …

Generative Biology: Towards Building the “ChatGPT” in Biology

03/11/2023

Dr. Jian Tang

We are currently at the intersection of the AI and biology revolutions. On one hand, generative AI has made great breakthroughs recent years such as the ChatGPT, which is trained on a huge amount of text and code data and is able to have conversations with humans by generating very …

Developing human sialidase as novel cancer therapeutics for degrading sialoglycans

01/08/2023

Dr. Li Peng

Immune checkpoint blockade has revolutionized cancer treatment. However, most patients encounter resistance not yet overcome by existing therapeutic approaches, urging the need for innovative therapies. Sialoglycans have emerged as a new dimension of immune checkpoints on various tumors that impair immune response. Cleaving off sialoglycans from tumors using a tumor-associated …

Recent Advance in Neutralizing Antibody (NAb) Assay in Immunogenicity Testing for Biotherapeutics

11/19/2022

Dr. Weifeng Xu

Biotherapeutics such as mAbs are immunogenic hence can induce anti-drug Abs (ADA) including neutralizing ADA (NAb). These ADA/NAb can induce broad side-effects such as injection site overreaction, reduced exposure, to life-threatening endogenous counterpart neutralization and allergic response. Hence immunogenicity testing including ADA screening, confirmation and titer as well as NAb …

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