Cell Line and Upstream Process Development for the Manufacture of Monoclonal Antibodies


Webinar Playback Time:

August 19th, Saturday, 9pm-10pm, EST (Sunday, August 20th, 9 am to 10 am Beijing Time)

Live Meeting Time:  July 15th, Saturday, 9pm-10pm, EST (Sunday, July 16th, 9 am to 10 am Beijing Time)

Abstract: Antibodies are the largest group of therapeutic proteins used to treat human diseases. A significant portion of the first wave of antibody drugs approved in the 80s and 90s were produced by hybridoma cells. Since then, recombinant monoclonal antibodies have dominated the antibody therapy field. The production platforms supporting these classes of molecules have significantly improved in recent years owing to the over 30 years of effort made by generations of scientists and engineers. The productivity of antibody in cell culture systems has increased steadily from 100 mg/L to over 10 g/L in fed-batch culture. Technological advancements have enabled construction of highly robust expression systems, more efficient production platforms, novel operational concepts and superior analytical tools. These improvements in turn, have led to more efficient (and more predictable) development operations, significantly lowering the cost of goods while increasing product quality. In this seminar, the presenter will provide an overview of the strategic considerations in production cell line engineering, process design and operation, as well as highlighting some of the key future directions using CHO cell lines as a production platform.

Speaker: Dr. Zhong Liu


Dr. Liu received his medical training at Peking Union Medical College from 1981 to 1988. He then obtained his Ph.D degree in Cell Biology from the University of Connecticut Health Center in 1994. Dr. Liu started his industrial career in 1994, and has held positions with increasing responsibilities with Berlex Biosciences (Shering AG), Schering-Plough Corp and Merck (MSD). In 2017, he joined Adello Biologics as the lead of upstream process development group. Dr. Liu has over 20 years of experience in production cell line generation and upstream process development for monoclonal antibodies, recombinant proteins and gene therapy vectors.

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Past Webinars

June 24th, 2017|Title: Fundamentals of therapeutic antibody discovery|Speaker: Dr. Zhijian Lu